Pfizer Halts Development of Aβ Antibody

RESEARCH NEWS 2011-11-02 Research News Pfizer Inc. has halted development of ponezumab, a passive immunotherapy targeting the C-terminal end of amyloid-β (Aβ). “Based on recent data from the ongoing studies, Pfizer has decided not to initiate further development of ponezumab in m

The Life and Times of the Human Brain Transcriptome

RESEARCH NEWS 2011-11-02 Research News Adapted from a story that originally appeared on the Schizophrenia Research Forum. 2 November 2011. A dynamic view of transcription in the human brain has been revealed in two papers published in Nature on 26 October 2011. Both studies track

PAPER Tosun D, Rosen H, Miller BL, Weiner MW, Schuff N

MRI patterns of atrophy and hypoperfusion associations across brain regions in frontotemporal dementia.

Neuroimage. 2012 Feb 1;59(3):2098-109. PubMed: 22036676

PAPER Tartaglia MC, Zhang Y, Racine C, Laluz V, Neuhaus J, Chao L, Kramer J, Rosen H, Miller B, Weiner M

Executive dysfunction in frontotemporal dementia is related to abnormalities in frontal white matter tracts.

J Neurol. 2011 Oct 29; PubMed: 22037958

PAPER Van Langenhove T, van der Zee J, Engelborghs S, Vandenberghe R, Santens P, Van den Broeck M, Mattheijssens M, Peeters K, Nuytten D, Cras P, De Deyn PP, De Jonghe P, Cruts M, Van Broeckhoven C

Ataxin-2 polyQ expansions in FTLD-ALS spectrum disorders in Flanders-Belgian cohorts.

Neurobiol Aging. 2012 May;33(5):1004.e17-20. PubMed: 22035589

PAPER Jeong JK, Seo JS, Moon MH, Lee YJ, Seol JW, Park SY

Hypoxia-inducible factor-1 alpha regulates prion protein expression to protect against neuron cell damage.

Neurobiol Aging. 2011 Oct 28; PubMed: 22036844

PAPER Xu T, Gong Z, Zhu WZ, Wang JF, Li B, Chen F, Deng XM

Remote ischemic preconditioning protects neurocognitive function of rats following cerebral hypoperfusion.

Med Sci Monit. 2011 Nov;17(11):BR299-304. PubMed: 22037731

PAPER Badiola N, de Oliveira RM, Herrera F, Guardia-Laguarta C, Gonçalves SA, Pera M, Suárez-Calvet M, Clarimon J, Outeiro TF, Lleó A

Tau enhances α-synuclein aggregation and toxicity in cellular models of synucleinopathy.

PLoS One. 2011;6(10):e26609. PubMed: 22039514

PAPER Lomazzo E, Hussmann GP, Wolfe BB, Yasuda RP, Perry DC, Kellar KJ

Effects of chronic nicotine on heteromeric neuronal nicotinic receptors in rat primary cultured neurons.

J Neurochem. 2011 Oct;119(1):153-64. PubMed: 21806615

PAPER Spoelgen R, Meyer A, Moraru A, Kirsch F, Vogt-Eisele A, Plaas C, Pitzer C, Schneider A

A novel flow cytometry-based technique to measure adult neurogenesis in the brain.

J Neurochem. 2011 Oct;119(1):165-75. PubMed: 21812782

PAPER Xu X, Warrington AE, Wright BR, Bieber AJ, Van Keulen V, Pease LR, Rodriguez M

A human IgM signals axon outgrowth: coupling lipid raft to microtubules.

J Neurochem. 2011 Oct;119(1):100-12. PubMed: 21824142

PAPER Blugeot A, Rivat C, Bouvier E, Molet J, Mouchard A, Zeau B, Bernard C, Benoliel JJ, Becker C

Vulnerability to depression: from brain neuroplasticity to identification of biomarkers.

J Neurosci. 2011 Sep 7;31(36):12889-99. PubMed: 21900567

PAPER Chorin E, Vinograd O, Fleidervish I, Gilad D, Herrmann S, Sekler I, Aizenman E, Hershfinkel M

Upregulation of KCC2 activity by zinc-mediated neurotransmission via the mZnR/GPR39 receptor.

J Neurosci. 2011 Sep 7;31(36):12916-26. PubMed: 21900570

PAPER Mizoguchi H, Nakade J, Tachibana M, Ibi D, Someya E, Koike H, Kamei H, Nabeshima T, Itohara S, Takuma K, Sawada M, Sato J, Yamada K

Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus.

J Neurosci. 2011 Sep 7;31(36):12963-71. PubMed: 21900575

PAPER Shakkottai VG, do Carmo Costa M, Dell'Orco JM, Sankaranarayanan A, Wulff H, Paulson HL

Early changes in cerebellar physiology accompany motor dysfunction in the polyglutamine disease spinocerebellar ataxia type 3.

J Neurosci. 2011 Sep 7;31(36):13002-14. PubMed: 21900579